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BQCA

Cat. No. M8368

All AbMole products are for research use only, cannot be used for human consumption.

BQCA Structure

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Biological Activity

BQCA is a potent muscarinic M1 receptor positive allosteric regulator with higher selectivity to M1 than M2-M5. It enhances M1 activity in vitro and in vivo trials and has oral bioavailability. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including the hippocampus, cortex, and striatum. BQCA binds to M1 in a allosteric manner, enhancing the binding and potency of ACh on the receptor. M1 activation is a proposed mechanism for increasing information processing in disease states such as Alzheimer's disease. M1 agonists are currently being investigated as potential compounds for the study of cognitive and negative symptoms in Alzheimer's disease and schizophrenia. BQCA has been shown to improve performance on cognitive tasks and increase brain blood flow.

Chemical Information
Molecular Weight 309.32
Formula C18H15NO4
CAS Number 338747-41-4
Solubility (25°C) DMSO: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Matthew C L Wakeham, et al. Structural Features of Iperoxo-BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy

[2] Simon Schramm, et al. Novel BQCA- and TBPB-Derived M 1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism

[3] Daniel P Holschneider, et al. Positive Allosteric Modulation of Cholinergic Receptors Improves Spatial Learning after Cortical Contusion Injury in Mice

[4] V Hepnarova, et al. The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease

[5] Brian Dean, et al. Changes in BQCA Allosteric Modulation of [(3)H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations

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Keywords: BQCA supplier, inhibitors, activators

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