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BpV(HOpic) is a protein tyrosine phosphatases (PTPs) and a potent PTEN inhibitor with IC50 of 14 nM. bpV(HOpic) potassium salt also inhibits the vascular endothelial PTP-β with IC50 of 4.9 μM and PTP-1βB with IC50 of 25.3 μM. Bpv(HOpic) enhances migration of C2C12 myoblasts and is associated with activation of PI3K/AKT and MAPK/ERK signalling pathways.
| Molecular Weight | 347.24 |
| Formula | C6H4K2NO8V |
| CAS Number | 722494-26-0 |
| Form | Solid |
| Solubility (25°C) | Water 40 mg/mL |
| Storage | -20°C, dry, sealed |
[4] Annette C Schmid, et al. FEBS Lett. Bisperoxovanadium compounds are potent PTEN inhibitors
| Related PTEN Products |
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| SF1670
SF1670 is a pTPN2 and PTEN inhibitor. |
| VO-OHpic trihydrate
VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor. |
| Ginkgolic acid 17:1
Ginkgolic acid 17:1, a natural product isolated from Ginkgo biloba, inhibits constitutive and inducible STAT3 activation by inducing PTEN and SHP-1 tyrosine phosphatases. In addition, Ginkgolic acid C17:1 has anticancer activity. |
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