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BPTES preferentially slows cell growth in D54 cells with mutant IDH1. BPTES also inhibits glutaminase activity, lowers glutamate and α-KG levels, and increases glycolytic intermediates.BPTES (10 μM) inhibits cell growth of mHCC 3–4 cells derived from LAP/MYC tumors. BPTES also inhibits growth of a MYC-dependent P493 cells by blocking DNA replication, leading to cell death and fragmentation.
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Source | Proc Natl Acad Sci U S A (2016). Figure 2. BPTES |
| Method | i.p. | |
| Cell Lines | mice | |
| Concentrations | 12.5 mg/kg | |
| Incubation Time | 3 d | |
| Results | Analysis of BPTES levels in blood, tumor, and normal pancreas by LC-MS revealed measurable drug in the tumors at 48 h postinjection (Fig. 2C), further corroborating the confocal microscopy and IVIS imaging data. |
| Molecular Weight | 524.68 |
| Formula | C24H24N6O2S3 |
| CAS Number | 314045-39-1 |
| Solubility (25°C) | DMSO 20 mg/mL warmed |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Jian Yang,et.al. Sci Rep. Targeting cellular metabolism to reduce head and neck cancer growth
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