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Bosentan Hydrate

Cat. No. M2278

All AbMole products are for research use only, cannot be used for human consumption.

Bosentan Hydrate Structure
Synonym:

Benzenesulfonamide Hydrate; Ro-47-0203 Hydrate

Size Price Availability Quantity
25mg USD 35 In stock
50mg USD 55 In stock
100mg USD 95 In stock
500mg USD 290 In stock
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Quality Control & Documentation
Biological Activity

Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.

Chemical Information
Molecular Weight 569.63
Formula C27H29N5O6S.H2O
CAS Number 157212-55-0
Solubility (25°C) DMSO 73 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hyo-Jung Lee, et al. Inhaled bosentan microparticles for the treatment of monocrotaline-induced pulmonary arterial hypertension in rats

[2] Marie-Camille Chaumais, et al. Additive protective effects of sacubitril/valsartan and bosentan on vascular remodelling in experimental pulmonary hypertension

[3] Hyo-Jung Lee, et al. Preparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols

[4] Kenneth I Ataga. Novel therapies in sickle cell disease

Related Endothelin Receptor Products
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Zibotentan (ZD4054) is a more selective and specific endothelin-A receptor (ETAR) antagonist with an IC50 value of 21 nM.

Ambrisentan

Ambrisentan is an orally active, highly selective antagonist of the endothelin-1 type A receptor.

Sitaxsentan sodium

Sitaxsentan (TBC-11251) is an orally active, highly selective antagonist of endothelin A receptors.

Macitentan

Macitentan is an orally-active, tissue-targeting dual ET receptor antagonist.

Bosentan

Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.

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Keywords: Bosentan Hydrate, Benzenesulfonamide Hydrate; Ro-47-0203 Hydrate supplier, Endothelin Receptor, inhibitors, activators

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