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Bombesin is a tetradecapeptide, which plays an important role in the release of gastrin and the activation of G-protein receptors. Bombesin is found to have stimulatory effects upon gastric and pancreatic secretions, release of gastrointestinal hormones, gallbladder contraction and bronchoconstriction. It is present in amphibian gastric endocrine cells, avian proventriculus endocrine cells and avian brain. In mammals it is present mainly in nerve cells and fibers. The only mammalian endocrine cell shown to date to have bombesin is the P-cell in fetal lung. Bombesin is shown to be a potent mitogen for Swiss 3T3 cells. In the presence of a low concentration (3.5%) of serum, bombesin stimulates 3T3 cell proliferation. In serum-free medium, bombesin induces DNA synthesis in the absence of any other added growth factor with IC50 of 1 nM.
| Molecular Weight | 1619.85 |
| Formula | C71H110N24O18S |
| CAS Number | 31362-50-2 |
| Solubility (25°C) | 0.05M acetic acid 20 mg/mL Water 1 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Related Bombesin Receptor Products |
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| MK-5046
MK-5046 is an orally active, potent, selective agonist of the orphan G protein-coupled receptor bombesin receptor subtype-3 (BRS-3) that is under evaluation for treatment of obesity. |
| Kuwanone H
Kuwanone H |
| ML-18
ML18 is Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM). |
| Ranatensin
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, which could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide, Bradykinin, or Norepinephrine. |
| RC-3095 TFA
RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist. |
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