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Boldine

Cat. No. M16194

All AbMole products are for research use only, cannot be used for human consumption.

Boldine Structure
Size Price Availability Quantity
5mg USD 30 In stock
10mg USD 40 In stock
20mg USD 55 In stock
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Quality Control & Documentation
Biological Activity

Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research. Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba).

Product Citations
Chemical Information
Molecular Weight 327.37
Formula C19H21NO4
CAS Number 476-70-0
Solubility (25°C) DMSO 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Juan P Toledo, et al. Front Neurosci. Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular Models of Alzheimer's Disease

[2] Devaraj Ezhilarasan, et al. J Biochem Mol Toxicol. Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice

[3] Emilio A Cafferata, et al. J Periodontol. Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance

[4] Leila Moezi, et al. Drug Res (Stuttg). Acute Boldine Treatment Induces Anti-convulsant Effects in Mice through its Antioxidant Activity

[5] Yeh Siiang Lau, et al. J Cardiovasc Pharmacol. Boldine Ameliorates Vascular Oxidative Stress and Endothelial Dysfunction: Therapeutic Implication for Hypertension and Diabetes

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Keywords: Boldine supplier, Apoptosis, inhibitors, activators

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