Free shipping on all orders over $ 500

BMS905

Cat. No. M42067

All AbMole products are for research use only, cannot be used for human consumption.

BMS905 Structure

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

BMS905 is an orally active TLR7 and TLR8 dual inhibitor (IC50s: 0.7 and 3.2 nM respectively).

Chemical Information
Molecular Weight 347.5
Formula C23H29N3
CAS Number 2205846-49-5
Form Solid
Storage Powder -20°C 3 years
References

[1] Ratna Kumar Sreekantha et al. ACS Med Chem Lett. Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8)

Related TLR Products
Vesatolimod (GS-9620)

Vesatolimod (GS-9620) is an effective, selective, oral toll-like receptor 7 (TLR7) agonist with an EC50 value of 291 nM.

Atractylenolide I

Atractylenolide I is a sesquiterpene obtained from the roots of Atractylenolide. Atractylenolide I has neuroprotective, anti-allergic, anti-inflammatory and anticancer activities. Atractylenolide I is an antagonist of TLR4 and can also reduce the phosphorylation of JAK2 and STAT3 in A375 cells.

Schaftoside

Schaftoside is a flavonoid found in a variety of Chinese herbs such as Eleusine indica. Schaftoside inhibited TLR4 and Myd88 expression. Schaftoside also reduced Drp1 expression and phosphorylation, and reduced mitochondrial division.

Procyanidin-B1

Procyanidin B1 is a polyphenolic flavonoid that exists in common fruits and can bind to TLR4/MD-2 complex, showing anti-inflammatory activity.

Polygalasaponin-F

Polygalasaponin F is an oleanane type triterpenoid saponin extracted from Polygala Japonica, which can reduce the release of inflammatory cytokine tumor necrosis factor α (TNFa). Polygalasaponin F reduces the secretion of neuroinflammatory cytokines by regulating the TLR4-PI3K/ Akt-NF-KB signaling pathway.

  Catalog
Abmole Inhibitor Catalog




Keywords: BMS905 supplier, TLR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.