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BMS-984923 is a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling.
| Molecular Weight | 374.82 |
| Formula | C22H15ClN2O2 |
| CAS Number | 1375752-78-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage | Powder -20°C |
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