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BMS-813160 is the first dual CCR2/CCR5 antagonist. BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively.
BMS-813160 (10-160 mg/kg; p.o. twice a day for two days) inhibits the migration of inflammatory monocytes and macrophages in mouse thioglycollate-induced peritonitis model, and shows excellent oral bioavailability.
Patent. CN113512587A 2021 Oct 19.
Patent. CN113512587A
BMS-813160 purchased from AbMole
| Molecular Weight | 484.64 |
| Formula | C25H40N8O2 |
| CAS Number | 1286279-29-5 |
| Solubility (25°C) | DMSO 20 mg/mL Ethanol 70 mg/mL |
| Storage | -20°C, protect from light |
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