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BMS-345541 hydrochloride is an anti-inflammatory, cell-permeable quinoxaline compound with a highly selective IKKbeta inhibitory activity. BMS-345541 blocks both joint inflammation and destruction in collagen-induced arthritis in mice. BMS-345541 hydrochloride induced apoptosis and an accumulation of cells in the G 2/M phase of the cell cycle via inhibition of IKK/NFκB signaling. T-ALL cells treated with BMS-345541 displayed nuclear translocation of FOXO3a and restoration of its functions, including control of p21(Cip1) expression levels. BMS-345541 hydrochloride is an allosteric site-binding inhibitor with a primary target of IKK-2 and blocks the NF-κB-dependent transcription in mice.
| Molecular Weight | 291.78 |
| Formula | C14H17N5.HCl |
| CAS Number | 547757-23-3 |
| Solubility (25°C) | Water ≥ 30 mg/mL DMSO 15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Oliver Herrmann, et al. Nat Med. IKK mediates ischemia-induced neuronal death
| Related IκB/IKK Products |
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BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). |
| SC-514
SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) with IC50 of 3-12 μM. |
| TPCA-1
TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM. |
| Bardoxolone Methyl
Bardoxolone Methyl is an IKK inhibitor with potent pro-apoptotic and anti-inflammatory activities, as well as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. |
| Bay 11-7085
BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
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