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BMS-265246 is a potent and selective CDK1/CDK2 selective inhibitor for CDK1/cycB and CDK2/cycE with IC50 of 6 and 9 nM, respectively. BMS-265246 inhibits the activity of CDK4/cycD with an IC50 of 0.23 μM and prevents A2780 Cytox with an IC50 of 0.76μM. BMS-265246 exhibits CDK1 and CDK2 potency that is 25- and 11-fold more potent versus CDK1 and CDK2, respectively.
| Molecular Weight | 345.34 |
| Formula | C18H17F2N3O2 |
| CAS Number | 582315-72-8 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CDK Products |
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Flavopiridol (Alvocidib) is a competitive broad-spectrum CDK inhibitor with IC50 of 30,170,100 nM against CDK1, CDK2 and CDK4, respectively. |
| R547
R547 is a potent and selective ATP-competitive CDK inhibitor, with Ki values of 2 nM, 3 nM and 1 nM for CDK1/cyclin B, CDK2/cyclin E and CDK4/cyclin D1, respectively. |
| JNJ-7706621
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| PD 0332991 HCL
PD-0332991 HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. |
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