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BMS 204352 is a potassium channel modulator. Originally developed as a potent opener of large-conductance, calcium-activated (Maxi-K, KCa1.1, BK) potassium channels, BMS 204352 also acts as a positive modulator at Kv7 (KCNQ) channels.
| Molecular Weight | 359.7 |
| Formula | C16H10ClF4NO2 |
| CAS Number | 187523-35-9 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Rikke Louise Schrder, et al. Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352
[2] Bo Skaaning Jensen. BMS-204352: a potassium channel opener developed for the treatment of stroke
[4] K B Mackay. BMS-204352 (Bristol Myers Squibb)
[5] R L Schrder, et al. KCNQ4 channel activation by BMS-204352 and retigabine
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