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BM212

Cat. No. M21923

All AbMole products are for research use only, cannot be used for human consumption.

BM212 Structure
Size Price Availability Quantity
5mg USD 135 In stock
10mg USD 216 In stock
25mg USD 400 In stock
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Quality Control & Documentation
Biological Activity

BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM.

Chemical Information
Molecular Weight 414.37
Formula C23H25Cl2N3
CAS Number 146204-42-4
Solubility (25°C) Ethanol 4.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Alice R Moorey, et al. Cell Surf. The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation

[2] Giovanna Poce, et al. PLoS One. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection

[3] Valentina La Rosa, et al. Antimicrob Agents Chemother. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

[4] M Biava, et al. Mini Rev Med Chem. New derivatives of BM212: A class of antimycobacterial compounds based on the pyrrole ring as a scaffold

[5] Mariangela Biava, et al. Bioorg Med Chem. Antimycobacterial compounds. New pyrrole derivatives of BM212

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Keywords: BM212 supplier, Antibiotic, inhibitors, activators

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