All AbMole products are for research use only, cannot be used for human consumption.
(±)-Blebbistatin (BLEB) is a small cell permeable selective myosin II inhibitor. Rabbit arterial SM was potently inhibited by BLEB (IC50 ∼5 µM) although this tissue does not express significant amounts of NMM II. Blebbistatin (BLEB) inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Blebbistatin (BLEB) rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
Due to the known light sensitivity of Blebbistatin (BLEB), it was always kept in the dark in the refrigerator until just prior to usage.
BioRxiv. 2025 Jan 13;632869.
The nucleocytoplasmic translocation of HINT1 regulates the maturation of cell density
Blebbistain purchased from AbMole
Sci China Life Sci. 2022 Oct;65(10):2031-2049.
Mechanical transmission enables EMT cancer cells to drive epithelial cancer cell migration to guide tumor spheroid disaggregation
Blebbistain purchased from AbMole
| Molecular Weight | 292.34 |
| Formula | C18H16N2O2 |
| CAS Number | 674289-55-5 |
| Solubility (25°C) | DMSO ≥ 15 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Related Myosin Products |
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| Omecamtiv mecarbil
Omecamtiv Mecarbil is a First-In-Class selective small molecule cardiac myosin activator that directly targets the contractile machinery of the heart, binding and increasing the number of cardiac myosin head regions interacting with actin during contraction. |
| (-)-Blebbistatin
(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. *The compound is unstable in solutions, freshly prepared is recommended |
| 2,3-Butanedione monoxime
2,3-Butanedione Monoxime (BDM) is a myosin ATPASE inhibitor. 2,3-Butanedione Monoxime is a skeletal and cardiac muscle contraction inhibitor. 2,3-Butanedione monoxime induces sarcoplasmic reticulum Ca2+ release. |
| TR100
TR100 is a specific anti-tropomyosin agent that preferentially disrupts the actin cytoskeleton of tumor cells. TR100 selectively disrupts Tm5NM1/2 containing actin filaments. |
| Mavacamten (MYK-461)
Mavacamten, also known as SAR-439152 and MYK-461, is the first (first-class) orally bioavailable allosteric and reversible selective inhibitor of Cardiac Myosin. The IC50 of bovine heart and human heart was 490 nM and 711 nM, respectively. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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