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BL-918

Cat. No. M21031

All AbMole products are for research use only, cannot be used for human consumption.

BL-918 Structure
Size Price Availability Quantity
1mg USD 45 In stock
2mg USD 65 In stock
5mg USD 105 In stock
10mg USD 157 In stock
25mg USD 295 In stock
50mg USD 475 In stock
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Quality Control & Documentation
Biological Activity

BL-918 is a potent, orally active activator of UNC-51-like kinase 1 (ULK1) with EC50 of 24.14 nM and Kd of 0.719 μM. BL-918 induces cytoprotective autophagy for Parkinson's disease.

Chemical Information
Molecular Weight 533.44
Formula C23H15F8N3OS
CAS Number 2101517-69-3
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wei Liu, et al. Acta Pharmacol Sin. BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy

[2] Sheng Zhang, et al. Autophagy. Negative pressure wound therapy improves bone regeneration by promoting osteogenic differentiation via the AMPK-ULK1-autophagy axis

[3] Liang Ouyang, et al. J Med Chem. Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment

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Keywords: BL-918 supplier, ULK, inhibitors, activators

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