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Bitopertin

Cat. No. M5464

All AbMole products are for research use only, cannot be used for human consumption.

Bitopertin Structure
Synonym:

RG1678, RO-4917838

Size Price Availability
5mg USD 70 4-7 Days
10mg USD 110 4-7 Days
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Quality Control & Documentation
Biological Activity

Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.

Chemical Information
Molecular Weight 543.46
Formula C21H20F7N3O4S
CAS Number 845614-11-1
Form Solid
Solubility (25°C) 100 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Umbricht D, et al. JAMA Psychiatry. Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study.

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Keywords: Bitopertin, RG1678, RO-4917838 supplier, GlyT, inhibitors, activators

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