Free shipping on all orders over $ 500

Bisindolylmaleimide X hydrochloride

Cat. No. M13855

All AbMole products are for research use only, cannot be used for human consumption.

Bisindolylmaleimide X hydrochloride Structure
Synonym:

BIM-X hydrochloride; Ro31-8425 hydrochloride

Size Price Availability Quantity
1mg USD 90 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective protein kinase C (PKC) inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM.

Chemical Information
Molecular Weight 460.96
CAS Number 145317-11-9
Solubility (25°C) DMSO 20.83 mg/mL
Storage 2-8°C, protect from light, dry, sealed
References

[1] Najwa Skafi, et al. J Cell Physiol. Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease

[2] Jose M Jimenez-Lopez, et al. J Pharmacol Exp Ther. Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells

[3] C S Chew, et al. Am J Physiol. Ca2+-independent protein kinase C isoforms may modulate parietal cell HCl secretion

Related PKC Products
Enzastaurin

Enzastaurin inhibits PKCβ, PKCα, PKCγ and PKCε with IC50's of 0.006, 0.039, 0.083 and 0.110 µM, respectively.

Go 6983

Go 6983 is a fast acting, lipid soluble, broad spectrum protein kinase C inhibitor.

Staurosporine

Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.

Zoledronic acid

Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects.

Dequalinium Chloride

Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Bisindolylmaleimide X hydrochloride, BIM-X hydrochloride; Ro31-8425 hydrochloride supplier, PKC, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.