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Bisdionin C 

Cat. No. M30570

All AbMole products are for research use only, cannot be used for human consumption.

Bisdionin C  Structure

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Quality Control & Documentation
Biological Activity

Bisdionin C is a potent GH18 chitinases inhibitor, with an IC50 of 0.2 μM for A. fumigatus ChiB1 (AfChiB1). Bisdionin C inhibits HCHT (human macrophage chitotriosidase) and acidic mammalian chitinase (AMCase) with IC50s of 8.3 and 3.4 μM, respectively.

Chemical Information
Molecular Weight 400.39
Formula C17H20N8O4
CAS Number 74857-22-0
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jeanette Wagener, et al. mBio. Candida albicans Chitin Increases Arginase-1 Activity in Human Macrophages, with an Impact on Macrophage Antimicrobial Functions

[2] Alexander W Schüttelkopf, et al. ACS Med Chem Lett. Bisdionin C-a rationally designed, submicromolar inhibitor of family 18 chitinases

[3] Tara E Sutherland, et al. Chem Biol. Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor

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