All AbMole products are for research use only, cannot be used for human consumption.
BS3 (bis(sulfosuccinimidyl)suberate) is an interamino acid crosslinker that is water soluble, non-cleavable, and membrane impermeable and is used in the synthesis of antibody coupled drugs (ADCs).
Applications:
- Crosslinking of cell surface proteins prior to cell lysis and immunoprecipitation.
- Identification of receptor ligand interactions by chemical cross-linking
- Identify weak or transient protein interactions by "immobilizing" them
- Identification of neighboring protein interactions
- Protein cross-linking in a one-step reaction to obtain biocouplings
- Immobilization of proteins on amino-coated surfaces
Sci Adv. 2025 Mar 07;11(10):eadq4266.
Isocyanic acid–mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation
BS3 (bis(sulfosuccinimidyl)suberate) purchased from AbMole
Cell Metab. 2024 Jan;S1550-4131(23)00465-5.
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis
BS3 (bis(sulfosuccinimidyl)suberate) purchased from AbMole
| Molecular Weight | 572.43 |
| Formula | C16H18N2O14S2Na2 |
| CAS Number | 82436-77-9 |
| Solubility (25°C) | Water 80 mg/mL DMSO 150 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Drug-Linker Conjugates for ADC Products |
|---|
| Mc-Val-Cit-PABC-PNP
Mc-Val-Cit-PABC-PNP is a histone-cleavable peptide linker for antibody-drug couplings (ADCs) that can be used for the synthesis of ADCs such as Brentuximab vedotin. |
| DM1-SMCC
DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make ADC. |
| CL2A-SN-38
CL2A-SN-38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an ADC. |
| Sulfo-SMCC sodium
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively. |
| DSS Crosslinker (Disuccinimidyl suberate)
DSS Crosslinker (Disuccinimidyl suberate) is a non-cleavable, cell membrane permeable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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