All AbMole products are for research use only, cannot be used for human consumption.
BIRB 796 (Doramapimod) is a protein kinase inhibitor of p38 MAPK. BIRB 796 (Doramapimod) has high picomolar affinity (Kd = 100 pM) for p38 MAP kinase and low nanomolar inhibitory activity (IC50 = 18 nM) against TNFα in THP-1 cell culture. The p38 inhibitor BIRB 796 (Doramapimod) binds tightly (Kd = 40 nM) to ABL (T315I) and inhibits the BMS-354825- and imatinib-resistant ABL (T315I) kinase.
Cell Signal. 2024 Jan ;8;115:111040.
MBIP promotes ESCC metastasis by activating MAPK pathway
BIRB796 purchased from AbMole
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Source | PLoS One (2013). Figure 4. BIRB796 |
| Method | Western blot | |
| Cell Lines | MDR cells | |
| Concentrations | 10 μM | |
| Incubation Time | 72 h | |
| Results | These data indicated that BIRB796 mediated the reversal of MDR by inhibiting the function of ABCB1, and not due to inhibition of ABCB1 expression. |
| Cell Experiment | |
|---|---|
| Cell lines | MM derived cell line |
| Preparation method | Growth inhibition assay. The growth inhibitory effect of BIRB 796 on MM cell line growth was assessed by measuring 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide (MTT) dye absorbance, as previously described. |
| Concentrations | 0, 100, 400nM |
| Incubation time | 72h |
| Animal Experiment | |
|---|---|
| Animal models | Male Crlj:CD1(ICR)mice |
| Formulation | saline |
| Dosages | 250, 500 or 1000 mg/kg |
| Administration | oral |
| Molecular Weight | 527.66 |
| Formula | C31H37N5O3 |
| CAS Number | 285983-48-4 |
| Solubility (25°C) | DMSO 66 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related p38 MAPK Products |
|---|
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GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. |
| Adezmapimod
Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. |
| SB 202190
SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase with IC50 values of 50 and 100 nM inhibiting p38α and p38β, respectively. |
| PH-797804
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| VX-702
VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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