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Bimosiamose

Cat. No. M14662

All AbMole products are for research use only, cannot be used for human consumption.

Bimosiamose Structure
Synonym:

TBC-1269

Size Price Availability
1mg USD 66 Out of stock
5mg USD 198 Out of stock
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Quality Control & Documentation
Biological Activity

Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects.

Chemical Information
Molecular Weight 862.91
CAS Number 187269-40-5
Solubility (25°C) DMSO 90 mg/mL
0.1 M NaOH 25 mg/mL (ultrasonic and adjust pH to 10 with NaOH)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Henrik Watz, et al. Inhaled pan-selectin antagonist Bimosiamose attenuates airway inflammation in COPD

[2] Florian B Mayr, et al. Effects of the pan-selectin antagonist bimosiamose (TBC1269) in experimental human endotoxemia

[3] Michael Meyer, et al. Tolerability and pharmacokinetics of inhaled bimosiamose disodium in healthy males

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Keywords: Bimosiamose, TBC-1269 supplier, inhibitors, activators

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