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Bilobalide is a compound with neuroprotective, antibacterial, and inhibitory effects.Bilobalide inhibits the hypoxia-induced reduction of ATP and under normoxic conditions increase glucose transport.Bilobalide is a inhibitor of GABA Receptor and SR.Bilobalide induced P19 cells differentiation into neurons in a concentration- and time-dependent manner.Bilobalide promoted neuronal differentiation through activation of Wnt/β-catenin signaling pathway. Exposure to bilobalide increased inactive GSK-3β phosphorylation, further induced the nuclear accumulation of β-catenin, and also up-regulated the expression of Wnt ligands Wnt1 and Wnt7a.Bilobalide significantly protected adipocytes from adverse effects of hypoxia in a dose-dependent manner by attenuating oxidative stress, inflammation and protecting mitochondria.The neuroprotective effects of bilobalide on cerebral I/R injury are associated with its inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation.
| Molecular Weight | 326.30 |
| Formula | C15H18O8 |
| CAS Number | 33570-04-6 |
| Solubility (25°C) | Ethanol 25mg/ml DMSO 25mg/ml |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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