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Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current.
| Molecular Weight | 509.29 |
| Formula | C21H20INO6 |
| CAS Number | 40709-69-1 |
| Solubility (25°C) | DMSO 150 mg/mL (ultrasonic) |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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