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BIBO 3304 trifluoroacetate is a high affinity NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2, Y4 and Y5 receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.
| Molecular Weight | 757.69 |
| Formula | C29H35N7O3.2CF3CO2H |
| CAS Number | 191868-14-1 |
| Solubility (25°C) | DMSO 75.77 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Neuropeptide Receptor Products |
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| JNJ-31020028
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors. |
| CYM 9484
CYM 9484 is a potent NPY Y 2 receptor antagonist. |
| L-152,804
L-152,804 is a potent, selective non-peptide NPY Y 5 receptor antagonist. |
| NTNCB hydrochloride
NTNCB hydrochloride is a potent and selective non-peptidic NPY Y 5 antagonist. |
| RF9
RF9 is a selective NPFF receptor antagonist (Ki values are 58 and 75 nM at hNPFF1 and hNPFF2 receptors respectively). |
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