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BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.
| Molecular Weight | 379.37 |
| Formula | C13H9N5O5S2 |
| CAS Number | 883065-90-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 37.94 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Steinbach and Akk. J Physiol. Modulation of GABAA receptor channel gating by pentobarbital.
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Products are for research use only. Not for human use. We do not sell to patients.
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