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BI-671800

Cat. No. M20981

All AbMole products are for research use only, cannot be used for human consumption.

BI-671800 Structure
Synonym:

AP-761, Cmpd A

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Biological Activity

BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS.

Chemical Information
Molecular Weight 501.5
Formula C25H26F3N5O3
CAS Number 1093108-50-9
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] David Miller, et al. Allergy Asthma Proc. A randomized study of BI 671800, a CRTH2 antagonist, as add-on therapy in poorly controlled asthma

[2] Ian P Hall, et al. Pulm Pharmacol Ther. Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment

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Keywords: BI-671800, AP-761, Cmpd A supplier, Prostaglandin Receptor, inhibitors, activators

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