All AbMole products are for research use only, cannot be used for human consumption.
BI-3406 is a highly potent and selective SOS1::KRAS inhibitor (IC50=6 nM), which selectively binds to SOS1 and blocks the interaction with KRAS, irrespective of the KRAS mutation. BI 3406 causes RAS GTP and pERK reduction and inhibits cell growth of KRAS mutated cell lines, carrying most of the typical KRAS mutations (i.e. G12D, G12V, G13D and others). BI 3406, when administered orally to tumour bearing mice, causes a dose dependent tumour static effect.
| Molecular Weight | 462.46 |
| Formula | C23H25F3N4O3 |
| CAS Number | 2230836-55-0 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | 2-8°C, dry, protect from light, sealed |
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Products are for research use only. Not for human use. We do not sell to patients.
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