All AbMole products are for research use only, cannot be used for human consumption.
Betulinic acid is a natural pentacyclic triterpenoid compound, which is an inhibitor of eukaryotic cell topoisomerase I with IC50 value of 5 μM. It has anti-inflammatory, anti-malaria, anti-AIDS and anti-tumor activities. Betulinic acid(Betulinic acid) is also an agonist of 20S proteasome. EC50=5.5μmol/L, Betulinic acid can specifically enhance cT-L activity of 20S proteasome.
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Betulinic acid purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | H9 lymphocytes |
| Preparation method | Incubating H9 lymphocytes ( 1 ×107 cells/ml) in the presence or absence of HIV-1 (IIIB isolate) for 1 h at 37 °C. Washing cells thoroughly to remove unadsorbed virions and resuspending in culture medium. Adding betulinic acid (diluted in test medium) to the culture medium. After incubation for 3 days at 37 °C, the cell densities of uninfected cultures are determined to assess toxicity of betulinic acid. Using a p24 antigen capture assay to determine the level of HIV infection in HIV-treated culture |
| Concentrations | |
| Incubation time | 3 days |
| Animal Experiment | |
|---|---|
| Animal models | LNCaP tumor xenograft model |
| Formulation | Diluted in corn oil containing 1% DMSO |
| Dosages | 10 and 20 mg/kg/d |
| Administration | Orally |
| Molecular Weight | 456.7 |
| Formula | C30H48O3 |
| CAS Number | 472-15-1 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
| Related NF-κB Products |
|---|
| QNZ
QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel. |
| Caffeic Acid Phenethyl Ester
Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. |
| Cepharanthine
Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. |
| JSH-23
Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| Methylthiouracil
Methylthiouracil is an anti-thyroid agent. Methylthiouracil inhibits TNF-α and IL-6 production and NF-κB and ERK1/2 activation. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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