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Beta-secretase Inhibitor IV is a potent cell-penetrating inhibitor that binds to the active site of BACE-1 and blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for HEK293-APPNFEV cells sAPP_NF). The IC50 of BACE-2, cathepsin D and renin were 230 nM, 7.6 μM and >50 μM, respectively.
| Molecular Weight | 578.72 |
| Formula | C31H38N4O5S |
| CAS Number | 797035-11-1 |
| Solubility (25°C) | DMSO: 100 mg/mL |
| Storage | 2-8℃, protect from light, dry, sealed |
[3] Ramn Cacabelos, et al. CNS Neurol Disord Drug Targets. Novel Therapeutic Strategies for Dementia
[4] Giuseppe Grasso. Mass Spectrom Rev. The use of mass spectrometry to study amyloid-β peptides
| Related BACE Products |
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| LY2886721
LY2886721 is an effective, selective, orally active inhibitor of beta-site amyloid precursor protein lyase 1 (BACE1) with an IC50 of 20.3 nM against recombinant human BACE1. LY2886721 showed higher selectivity for BACE1 than cathepsin D, pepsin and renin, but lacked selectivity for BACE2 (IC50 was 10.2 nM). LY2886721 crosses the blood-brain barrier and can be used to study Alzheimer's disease. |
| AZD3839
AZD3839 is a potent and selective inhibitor of human BACE1 with Ki of 26.1 nM. |
| Lanabecestat
Lanabecestat (AZD3293, LY3314814) is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. |
| Eslicarbazepine Acetate
Eslicarbazepine acetate is an antiepileptic drug. |
| Verubecestat (MK-8931)
Verubecestat (MK-8931) is an orally active, high-affinity (beta-secretase 1) BACE1 and BACE2 inhibitor, with Ki values of 2.2 nM and 0.38 nM, respectively. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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