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β-Mangostin

Cat. No. M4356

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β-Mangostin Structure
Synonym:

β-Mangostin

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5mg USD 160 In stock
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Biological Activity

Beta-mangostin (β -mangostin) is a compound of oxyxanthone present in Cratoxylum arborescens, which has antibacterial and antimalarial activities. The MIC value of beta-mangostin against M. tuberculosis was 6.25 μg/mL. Beta-mangostin showed anti-malarial activity in vitro with IC50 value of 3.00 μg/mL against P. falciparum. Beta-mangostin has strong anticancer activity against various cancers, such as hepatocellular carcinoma and leukemia.

Chemical Information
Molecular Weight 424.49
Formula C25H28O6
CAS Number 20931-37-7
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kaiqiang Li, et al. Cytotoxic and Antiproliferative Effects of β-Mangostin on Rat C6 Glioma Cells Depend on Oxidative Stress Induction via PI3K/AKT/mTOR Pathway Inhibition

[2] Chun-Shiang Lin, et al. β-Mangostin inhibits the metastatic power of cervical cancer cells attributing to suppression of JNK2/AP-1/Snail cascade

[3] Fatima Abdelmutaal Ahmed Omer, et al. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G 0/G 1 cell-cycle arrest

[4] Chien-Feng Huang, et al. β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways

[5] Thiruventhan Karunakaran, et al. Acetyl- and O-alkyl- derivatives of β-mangostin from Garcinia mangostana and their anti-inflammatory activities

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Keywords: β-Mangostin, β-Mangostin supplier, Antibiotic, inhibitors, activators

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