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β-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. β-Lapachone is a topoisomerase I inhibitor. β-Lapachone (25 μM) inhibits camptothecin-induced DNA cleavage. β-Lapachone (10-40 μM) significantly reduces the colony-forming ability of CHO cells, and is cytotoxic in S phase. β-Lapachone at above 10 μM, causes a heavy DNA-strand breaks in CHO cells. β-Lapachone (10 μM) suppresses JCPyV replication in IMR-32 cells.
| Molecular Weight | 242.27 |
| Formula | C15H14O3 |
| CAS Number | 4707-32-8 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Narmin Mokarizadeh, et al. An evaluation on potential anti-inflammatory effects of β-lapachone
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