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β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. β-Glycerophosphate disodium salt hydrate is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression.
Genes & Diseases. 2025 Nov 10; .
Targeting MDK alleviates bone loss via dual regulation of osteogenic differentiation and inflammatory cytokine expression
β-Glycerophosphate disodium salt hydrate purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | BVSMC bovine vascular smooth muscle cells |
| Preparation method | BVSMCs were cultured in DMEM medium containing 10 mmol/L sodium pyruvate and 15% FBS. After confluence, the cells were seeded in DMEM containing 10 mmol/L sodium pyruvate, 15% FBS, 10 mmol/L β-glycerophosphate, 10-7 mol/L insulin and 50 μg/mL ascorbic acid, and cultured for 14 days (calcification culture) base). The medium was changed every 3 days. In some experiments, only beta-glycerophosphate was used to induce BVSMC calcification. In addition, in the time course experiment, cells were selected as controls before culturing in calcified medium (defined as day 0). |
| Concentrations | 10 mmol/L |
| Incubation time | 14 d |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 306.11 |
| Formula | C3H9O6PNa2.5(H2O) |
| CAS Number | 13408-09-8 |
| Solubility (25°C) | Water ≥ 80 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
| Related Phosphatase Products |
|---|
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CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM. |
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Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. |
| Sal003
Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. |
| Rhein-8-O-β-D-glucopyranoside
Rhein-8-glucoside calcium, a anthraquinone compound isolated from EtOH extract of Saussurea lappa root. Rhein-8-glucoside calcium is an hPTP1B inhibitor with an IC50 value of 11.5 μM. Rhein-8-glucoside calcium has antibacterial effects. |
| Silydianin
Silydianin, the active ingredient of silythistle, has anti-collagenase and anti-elastic enzyme activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 value of 17.38 μM. Silydianin inhibited the production and release of oxidation products in vitro. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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