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Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. Bergapten acts as a natural antitumoral agent, able to deplete ERα from breast cancer tamoxifen-sensitive and resistant cells, thereby retraining the effect of membrane signals targeting ERα and in such way its mitogenic potentiality. Bergapten can effectively protect C57BL/6J mice from acetaminophen (APAP)-induced hepatotoxicity and possesses an antioxidative activity, and does not cause liver injury at the protective doses.
| Molecular Weight | 216.19 |
| Formula | C12H8O4 |
| CAS Number | 484-20-8 |
| Solubility (25°C) | DMSO 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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