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Berberrubine chloride is an active metabolite of berberine, attenuates ulcerative colitis in mice model.
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Source | Asian Pac J Cancer Prev (2015). Figure 4. Berberrubine |
| Method | DPPH assay | |
| Cell Lines | HT1080 cells | |
| Concentrations | 0.1 and 1.0 μM | |
| Incubation Time | 7 d | |
| Results | In contrast, B2-B4 did not show the significant difference in CAT expression if compared with B1. Interestingly, compounds B1-B4 exhibited a significant up-regulation of SOD expression in a dose dependent fashion (p<0.05) compared with the untreated cells. |
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Source | Asian Pac J Cancer Prev (2015). Figure 3. Berberrubine |
| Method | MTT assay | |
| Cell Lines | HT1080 cells | |
| Concentrations | 0.1 and 1.0 μM | |
| Incubation Time | 7 d | |
| Results | The result of cytotoxicity (Figure 3) showed that compounds B1, B2, and B4 significantly decreased the viability of HT1080 at all concentrations with both dose and time-dependent fashion (p<0.05). |
| Cell Experiment | |
|---|---|
| Cell lines | AMC5 cells |
| Preparation method | AMC5/B1 cells were selected by intermittent exposure of surviving cells to increasing concentrations of berberrubine. AMC5 cells in 100-mm plastic dishes were first exposed to berberrubine at 10 μM to reduce the surviving fraction to 20 to 30% and were allowed to grow in the absence of selecting drug until they reached the initial cell density or greater. |
| Concentrations | 10 μM |
| Incubation time | 16 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6J mice |
| Formulation | |
| Dosages | 25, 50 mg/kg |
| Administration | p.o. |
| Molecular Weight | 357.79 |
| Formula | C19H16ClNO4 |
| CAS Number | 15401-69-1 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Metabolite/Endogenous Metabolite Products |
|---|
| 2'-Deoxyinosine
2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability. |
| Ribitol
Ribitol (Adonitol) is a crystalline pentose alcohol formed by the reduction of ribose. |
| Glycodeoxycholic Acid
Glycodeoxycholic Acid is an endogenous metabolite. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis. |
| Glycolithocholic acid
Glycolithocholic acid, an endogenous metabolite, is a glycine conjugated secondary bile acid. Glycolithocholic acid can be used to study ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH0) and primary sclerosing cholangitis (PSC). |
| 4-Aminohippuric Acid
4-Aminohippuric acid is a typical substrate of organic anion transport systems. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow. |
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