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Benzyl butyl phthalate can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs).
| Molecular Weight | 312.36 |
| Formula | C19H20O4 |
| CAS Number | 85-68-7 |
| Form | Liquid |
| Solubility (25°C) | Water 90 mg/mL (ultrasonic) |
| Storage | -20°C |
[5] No authors listed. IARC Monogr Eval Carcinog Risks Hum. Butyl benzyl phthalate
| Related Aryl hydrocarbon Receptor Products |
|---|
| StemRegenin 1
StemRegenin 1 is an AhR inhibitor with IC50 of 127 nM. |
| Carbidopa
Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM. |
| Diosimin
Diosimin is a flavonoid glycoside found in citrus fruits, hyssop, and rosemary. Diosimin is also an agonist of the aryl hydrocarbon receptor (AhR), capable of upregulating the expression of p53, caspase 3, and caspase 9 in A431 cells, while downregulating the levels of Bcl-2 and matrix metalloproteinases (MMP-2 and MMP-9). Its metabolite, diosmetin, inhibits 3H-dopamine uptake in a dose-dependent manner with an IC50 value of 4 μM. |
| CH-223191
CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM. *The compound is unstable in solutions, freshly prepared is recommended |
| Perillaldehyde
Perillaldehyde inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway. |
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