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Benpyrine racemate ((Rac)-Benpyrine) is a racemate of Benpyrine, Benpyrine racemate ((Rac)-Benpyrine) is a potent and orally active TNF-α inhibitor and has the potential for TNF-α mediated inflammatory and autoimmune disease research. (Rac)-Benpyrine (5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages. In vivo, (Rac)-Benpyrine (25-50 mg/kg/day; oral gavage; 3 weeks) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down.
| Molecular Weight | 308.34 |
| Formula | C16H16N6O |
| CAS Number | 1333714-43-4 |
| Solubility (25°C) | DMSO 9 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
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