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Bendazol

Cat. No. M20781

All AbMole products are for research use only, cannot be used for human consumption.

Bendazol Structure
Synonym:

2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan

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Quality Control & Documentation
Biological Activity

Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α.

Chemical Information
Molecular Weight 208.26
Formula C14H12N2
CAS Number 621-72-7
Solubility (25°C) DMSO 42 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Liyang Tong, et al. Ophthalmic Physiol Opt. Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF-1α protein in young rabbits

[2] Zhixia Huo, et al. J Sep Sci. Base-deactivated and alkaline-resistant chromatographic stationary phase based on functionalized polymethylsilsesquioxane microspheres

[3] Wali Khan, et al. Pak J Pharm Sci. Albendazole in the treatment of Hymenolepiasis in school children

[4] E V Eliseeva, et al. Bull Exp Biol Med. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension

[5] E A Kuzubova, et al. Eksp Klin Farmakol. [Effect of dibazol (bendazol) on the generative function in rats]

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Imperatorin

Imperatorin is a potent NO synthesis inhibitor with an IC50 of 9.2 μmol and a BChE inhibitor with an IC50 of 31.4 μmol. Imperatorin is a weak agonist of TRPV1 with an EC50 of 12.6±3.2 μM.
Crocin-II

Crocin II, isolated from the fruit of Gardenia jasminoides, has antioxidant, anticancer and antidepressant activities. Crocin II inhibited NO production with IC50 value of 31.1 μM. Crocin II inhibited the expression of iNOS and COX-2 protein and M-RNA.
Madecassic-acid

Madecassic acid was isolated from Centella asiatica (umbelliferae). Madecassic acid showed inhibition of iNOS, COX-2, TNF-α, IL-1beta and IL-6, and had anti-inflammatory effect by down-regulation of NF-κB activation in RAW 264.7 macrophages.
Irisflorentin

Irisflorentin, a naturally occurring isoflavone, is an abundant active ingredient in Rhizoma Belamcandae. Irisflorentin significantly reduced the transcription and translation levels of iNOS and NO production.
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Keywords: Bendazol, 2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan supplier, NO Synthase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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