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Belvarafenib (GDC5573, HM95573, RG6185) is a selective and orally bioavailable pan-RAF kinase inhibitor with IC50 values of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF(V600E) and CRAF kinases, respectively. Belvarafenib also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively.
| Molecular Weight | 478.93 |
| Formula | C23H16ClFN6OS |
| CAS Number | 1446113-23-0 |
| Solubility (25°C) | DMSO 12 mg/mL |
| Storage | 4°C, sealed |
[4] No authors listed. Cancer Discov. ARAF Mutations Limit Response to RAF Dimer Inhibition
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