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Belatacept (BMS 224818) is a selective T-cell costimulation blocker. Belatacept (BMS 224818) is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4, which is a molecule crucial in the regulation of T cell costimulation, selectively blocking the process of T-cell activation. Belatacept binds to CD 80/86 ligands and thereby inhibits the CD-28-mediated T-cell costimulation. Belatacept can be used in the research of Immunosuppression in organ transplants.
Belatacept (20 mg/kg; intravenous injection) displays immunosuppressive activities in monkeys immunized with sheep red blood cell.
| CAS Number | 706808-37-9 |
| Solubility (25°C) | Water 50 mg/mL |
| Storage | Store at 4°C, do not freeze |
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