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Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM.
| Molecular Weight | 265.27 |
| Formula | C11H15N5O3 |
| CAS Number | 249503-25-1 |
| Form | Solid |
| Solubility (25°C) | Water 1.53 mg/mL (Need ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Ray Taylor, et al. Viruses. Activity of Galidesivir in a Hamster Model of SARS-CoV-2
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