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BCATc Inhibitor 2

Cat. No. M21208

All AbMole products are for research use only, cannot be used for human consumption.

BCATc Inhibitor 2  Structure
Size Price Availability Quantity
5mg USD 150 In stock
10mg USD 250 In stock
25mg USD 500 In stock
50mg USD 780 In stock
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Quality Control & Documentation
Biological Activity

BCATc Inhibitor 2 is a sulfonyl hydrazide that inhibits BCATc with IC50s of 0.81 for human and IC50 s of 0.2 µM for rat. It is 15-fold selectivity over BCATm. It has also been used to block calcium influx into neurons with IC50 of 4.8 µM following inhibition of glutamate uptake and to demonstrate neuroprotective efficacy in an in vivo rat model of neurodegeneration.

Chemical Information
Molecular Weight 418.7748096
Formula C16H10ClF3N2O4S
CAS Number 406191-34-2
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage 4°C, protect from light, dry, sealed
References

[1] Zhuo Lu, et al. Front Pharmacol. BCATc inhibitor 2 ameliorated mitochondrial dysfunction and apoptosis in oleic acid-induced non-alcoholic fatty liver disease model

[2] Mohammad Shamsul Ola, et al. Neurotox Res. Gabapentin Attenuates Oxidative Stress and Apoptosis in the Diabetic Rat Retina

[3] Julio Caballero, et al. Mol Divers. Docking and quantitative structure-activity relationship studies for sulfonyl hydrazides as inhibitors of cytosolic human branched-chain amino acid aminotransferase

[4] S M Hutson, et al. J Nutr. Function of leucine in excitatory neurotransmitter metabolism in the central nervous system

[5] S M Hutson, et al. J Neurochem. Role of branched-chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism

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Keywords: BCATc Inhibitor 2 supplier, inhibitors, activators

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