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BAY-60-7550 is a potent Type 2 cyclic nucleotide phosphodiesterases (PDE2) inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). BAY-60-7550 is an analog of EHNA, which is more than 100-fold more potent and is highly selective for PDE2A.
 |
Source | Neurobiol Aging (2015). Figure 1. BAY-60-7550 |
| Method | i.v. | |
| Cell Lines | mice | |
| Concentrations | 3 mg/kg | |
| Incubation Time | 24 h | |
| Results | Bay 60-7550-treated mice (3 mg/kg) took significantly less time to reach the platform position, and made more crossings over the platform, than stressed mice |
| Cell Experiment | |
|---|---|
| Cell lines | human distal pulmonary artery smooth muscle cells |
| Preparation method | Cell proliferation. Growth of human distal pulmonary artery smooth muscle cells isolated from patients with idiopathic pulmonary arterial hypertension (IPAH) or control cells from adults undergoing transplant or lung resection for suspected malignancy, were monitored as we have described previously 29 following treatment with BAY 60-7550 (1μmol/L), ANP (1μmol/L), DETA-NONOate (10μmol/L), or treprostinil (1μmol/L), alone or in combination. |
| Concentrations | 1μmol/L |
| Incubation time | unknow |
| Animal Experiment | |
|---|---|
| Animal models | Oxidative Stress on Behavior in mice |
| Formulation | dissolved in 50% dimethyl sulfoxide (Fisher Scientific Co., Pittsburgh, PA) |
| Dosages | 3 mg/kg; given 30 min before each BSO treatment |
| Administration | i.p. |
| Molecular Weight | 476.57 |
| Formula | C27H32N4O4 |
| CAS Number | 439083-90-6 |
| Solubility (25°C) | DMSO 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Ren et al. Hypertension. Mechanisms of carbon monoxide attenuation of tubuloglomerular feedback.
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