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BAY 41-8543 is a guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μM. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro. Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.
| Molecular Weight | 420.44 |
| Formula | C21H21FN8O |
| CAS Number | 256498-66-5 |
| Solubility (25°C) | DMSO 4.2 mg/mL (with gentle warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Guanylate Cyclase Products |
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| A 350619 hydrochloride
A 350619 hydrochloride is a soluble guanylyl cyclase (sGC) activator. |
| BAY 41-2272
BAY 41-2272 is a soluble guanylyl cyclase (sGC) activator. |
| Linaclotide
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| Ebselen Oxide
Ebselen oxide is a potent inhibitor of a-Methylacyl coenzyme A racemase (AMACR). |
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