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BAY 41-2272 is a activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.
| Molecular Weight | 360.39 |
| Formula | C20H17FN6 |
| CAS Number | 256376-24-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 36.04 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Guanylate Cyclase Products |
|---|
| Riociguat (BAY 63-2521)
Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the research of ipulmonary hypertension. |
| A 350619 hydrochloride
A 350619 hydrochloride is a soluble guanylyl cyclase (sGC) activator. |
| BAY 41-8543
BAY 41-8543 is a guanylyl cyclase (sGC) stimulator. |
| Linaclotide
Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. |
| Ebselen Oxide
Ebselen oxide is a potent inhibitor of a-Methylacyl coenzyme A racemase (AMACR). |
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