All AbMole products are for research use only, cannot be used for human consumption.
Baicalin facilitated the transfer of electrons from Fe (2+) to dissolved oxygen. Baicalin has the capacity to protect IEC-6 cells and the intercellular tight junctions from LPS-induced injury. The mechanisms may be associated with inhibiting the production of inflammatory cytokines, and up-regulating the mRNA and protein expression of ZO-1. Baicalin had no effects on the pharmacokinetics of caffeine and its metabolites in vivo, following single oral administration in rats. Anti-inflammatory properties of baicalin may be resulted from the inhibition of IL-6, IL-8, and TNF-α expression via preventing signaling NF-κB pathway in HBE16 airway epithelial cells.
| Cell Experiment | |
|---|---|
| Cell lines | OVCAR-3, A2780/CP70, IOSE-364 |
| Preparation method | Cells (5000/well) were seeded into 96-well plates and incubated for 24 h before being treated with zero to 160 μg/mL Baicalin and Baicalein (containing 10% FBS RPMI 1640) in triplicates for another 24 h. |
| Concentrations | 160 μg/mL |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 446.36 |
| Formula | C21H18O11 |
| CAS Number | 21967-41-9 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related GABA Receptor Products |
|---|
| SKF 89976A hydrochloride
SKF 89976A hydrochloride is a potent GABA uptake inhibitor, selective for GAT-1. |
| Alpidem
Alpidem is a potent antagonist of peripheral benzodiazepine receptor (PBR). |
| (R)-Baclofen
(R)-baclofen, a gamma-aminobutyric acid derivative and agonist at GABA-B receptors, inhibits nerve conduction in the central nervous system and can be used in studies related to spasticity. |
| (+)-Bicuculline
(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
| Bemegride
Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
