All AbMole products are for research use only, cannot be used for human consumption.
Bafilomycin A1 (BafA1) is a toxic macrolide antibiotic derived from Streptomyces griseus. Bafilomycin A1 inhibits the short circuit current induced by the outer mantle epithelium (OME). The IC50 and maximum inhibition dose of Bafilomycin A1 are 0.17 μM and 0.5 μM, respectively. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). The most used bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.
Autophagy. 2025 Oct 14; .
Lnc-HZ14 promotes LLPS-mediated SPHK1 aggrephagy degradation to suppress trophoblast cell proliferation in unexplained recurrent miscarriage
Bafilomycin A1 purchased from AbMole
Free Radic Biol Med. 2025 Aug 20; .
Epimedokoreanin B blocks autophagic flux to inhibit progression of triple negative breast cancer through targeting MCOLN1/TRPML1 channel
Bafilomycin A1 purchased from AbMole
NPJ Regen Med. 2025 Jul 23;10(1):35.
Exogenous melatonin alleviates premature ovarian failure by regulating granulosa cell autophagy
Bafilomycin A1 purchased from AbMole
Oxid Med Cell Longev. 2022 Jan 25;2022:8096009.
Interaction between TRPML1 and p62 in Regulating Autophagosome-Lysosome Fusion and Impeding Neuroaxonal Dystrophy in Alzheimer's Disease
Bafilomycin A1 purchased from AbMole
Transl Psychiatry. 2021 Aug 5;11(1):421.
BRUCE silencing leads to axonal dystrophy by repressing autophagosome-lysosome fusion in Alzheimer's disease
Bafilomycin A1 purchased from AbMole
Mol Immunol. 2020 Jan;117:12-19.
Toll-like receptor 4 knockout protects against diabetic-induced imbalance of bone metabolism via autophagic suppression.
Bafilomycin A1 purchased from AbMole
| Molecular Weight | 622.83 |
| Formula | C35H58O9 |
| CAS Number | 88899-55-2 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Related Proton Pump Products |
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| Omeprazole
Omeprazol is a first-in-class proton pump inhibitor (PPI) used in the treatment of dyspepsia, laryngopharyngeal reflux (LPR) and Zollinger–Ellison syndrome. |
| Dexlansoprazole
Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties. |
| Tenatoprazole
Tenatoprazole is a procompound of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. |
| Esomeprazole Sodium
Esomeprazole Sodium is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg. |
| Esomeprazole Magnesium
Esomeprazole Magnesium is a proton pump inhibitor to reduce gastric acid secretion. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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