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Azoramide is a dual-function endoplasmic reticulum (ER) modulator. Azoramide improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems. Azoramide exhibits potent antidiabetic efficacy in two independent mouse models of obesity by improving insulin sensitivity and pancreatic β cell function. Azoramide enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity.
| Molecular Weight | 308.83 |
| Formula | C15H17ClN2OS |
| CAS Number | 932986-18-0 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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