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Vistusertib (AZD2014) is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity. Vistusertib (AZD2014) inhibits biomarkers pAKTSer473 and pNDRG1Thr346. Vistusertib (AZD2014) has broad antiproliferative activity across multiple tumour cell lines. Vistusertib (AZD2014) induces growth inhibition and cell death in breast cancer cell lines, including ER+ cell lines with acquired resistance to hormone therapy. Vistusertib (AZD2014) induces tumour growth inhibition against several xenograft models including a human primary explant model of ER+ breast cancer refractory to tamoxifen.
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Source | Cell Physiol Biochem (2018). Figure 4. AZD2014 |
| Method | Flow cytometric analysis | |
| Cell Lines | NSCLC cell | |
| Concentrations | - | |
| Incubation Time | 24 h | |
| Results | When mTOR was inhibited in anti-miR-99a-A549 cells by AZD2014, the cells became more sensitive to radiation than control cells and the levels of anti-apoptosis markers were reduced |
| Molecular Weight | 462.54 |
| Formula | C25H30N6O3 |
| CAS Number | 1009298-59-2 |
| Solubility (25°C) | DMSO 18 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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