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AZD 3988 is a potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.
| Molecular Weight | 456.44 |
| Formula | C23H22F2N4O4 |
| CAS Number | 892489-52-0 |
| Solubility (25°C) | 1eq. NaOH 4.56 mg/mL (with gentle warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related DGAT Products |
|---|
| A-922500
A-922500 (DGAT-1 Inhibitor 4a) is a potent and selective DGAT-1 inhibitor with IC50 values of 9 and 22 nM at human and mouse DGAT-1 respectively. |
| AZD7687
AZD7687 is a reversible and selective DGAT1 inhibitor with IC50 value of 80 nM. |
| PF-04620110
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
| PF-06424439 methanesulfonate
PF-06424439 methanesulfonate is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2) with an IC50 of 14 nM. |
| T863
T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. |
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