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Azamulin

Cat. No. M8364

All AbMole products are for research use only, cannot be used for human consumption.

Azamulin Structure

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Quality Control & Documentation
Biological Activity

Azamulin is a derivative of the antibiotic pleuromutilin. The compound is a very specific inhibitor of the CYP3A family (IC50 = 0.03-0.24 μM). Azamulin is 15 and 13 fold more active against CYP3A4 compared to CYP3A5 or CYP3A7, respectively, and is at least 100 fold selective over other CYP isoforms, with the exception of CYP2J2 (approximately 50-fold).

Chemical Information
Molecular Weight 478.65
Formula C24H38N4O4S
CAS Number 76530-44-4
Solubility (25°C) DMSO: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hugues Chanteux, et al. Application of Azamulin to Determine the Contribution of CYP3A4/5 to Drug Metabolic Clearance Using Human Hepatocytes

[2] Irina F Sevrioukova. Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, Azamulin and 6',7'-Dihydroxybergamottin

[3] Ranjana Mitra, et al. CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR

[4] Siamak Cyrus Khojasteh, et al. Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity

[5] David M Stresser, et al. Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible

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Keywords: Azamulin supplier, inhibitors, activators

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